Prurigo nodularis
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References
Prurigo nodularis é uma doença de pele de longa duração caracterizada por múltiplas protuberâncias e nódulos firmes, geralmente encontrados nas partes externas dos braços e pernas. Essas saliências podem variar em cor, do tom de pele ao rosa, e causam coceira intensa. Eles podem afetar pessoas de qualquer idade e estão frequentemente associados a outras doenças de pele que causam coceira crônica, como a dermatite atópica. As opções de tratamento incluem medicamentos anti-coceira fortes, medicamentos que afetam o sistema imunológico e medicamentos direcionados ao sistema nervoso. O manejo do prurigo nodular geralmente envolve terapia de longo prazo.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
O tratamento geralmente envolve o uso de cremes ou injeções de esteróides na área afetada. Em casos mais graves ou persistentes, podem ser necessários tratamentos como fototerapia ou medicamentos que suprimem o sistema imunológico. A talidomida e a lenalidomida são opções para casos graves, mas podem ter efeitos colaterais graves. Tratamentos mais recentes (opioid receptor antagonists, neurokinin-1 receptor antagonists) mostram-se promissores no tratamento do prurigo nodularis com menos efeitos colaterais em comparação com a talidomida ou lenalidomida.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo é uma doença de pele caracterizada por coceira de longa duração (durando mais de 6 semanas) , lesões cutâneas relacionadas a arranhões e histórico de coceiras frequentes. Envolve neuroinflamação e fibrose na pele.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis é um problema de pele duradouro marcado por nódulos que coçam. Não sabemos exatamente o que causa isso, mas parece que problemas imunológicos e nervosos desempenham um papel no ciclo de coceira e coceira. No momento, não existem tratamentos aprovados pelo FDA dos EUA especificamente para prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Tratamento - Medicamentos OTC
Lavar a área da lesão com sabão não ajuda em nada e pode piorar a situação. Pomadas esteróides de venda livre podem ajudar a aliviar os sintomas, mas geralmente precisam ser aplicadas por várias semanas para melhorar. Continuar a tomar anti-histamínicos também ajuda a aliviar a coceira.
#OTC steroid ointment
#OTC antihistamine
○ Tratamento
#Intralesional triamcinolone injection